Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation-Reference-Cited by-同舟云学术

Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation

Published:2020 Issue:78 Volume:56 Page:11677-11680
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Del Vecchio Antonio¹²³⁴⁵,Talbot Alex¹²³⁴⁵,Caillé Fabien⁶⁷⁸⁹¹⁰^ORCID,Chevalier Arnaud¹²³⁴⁵,Sallustrau Antoine¹²³⁴⁵,Loreau Olivier¹²³⁴⁵,Destro Gianluca¹²³⁴⁵,Taran Frédéric¹²³⁴⁵^ORCID,Audisio Davide¹²³⁴⁵^ORCID

Affiliation:

1. Université Paris-Saclay

2. Service de Chimie Bio-organique et Marquage (SCBM)

3. CEA/DRF/JOLIOT

4. Gif sur Yvette

5. France

6. UMR 1023 IMIV

7. Service Hospitalier Frédéric Joliot

8. CEA

9. Inserm

10. Université Paris Sud

Abstract

A procedure which allows labelling cyclic carbamates with all carbon isotopes has been developed. This protocol valorizes carbon dioxide, the universal building block for radiolabeling. A series of pharmaceuticals were obtained and a disconnection/reconnection strategy was implemented.

Funder

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC05031H

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