The rippled β-sheet layer configuration—a novel supramolecular architecture based on predictions by Pauling and Corey-Reference-Cited by-同舟云学术

The rippled β-sheet layer configuration—a novel supramolecular architecture based on predictions by Pauling and Corey

Published:2022 Issue:31 Volume:13 Page:8947-8952
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hazari Amaruka¹,Sawaya Michael R.²,Vlahakis Niko²,Johnstone Timothy C.¹^ORCID,Boyer David²,Rodriguez Jose²,Eisenberg David²,Raskatov Jevgenij A.¹^ORCID

Affiliation:

1. Dept. of Chemistry and Biochemistry, UCSC, 1156 High Street, Santa Cruz, CA 95064, USA

2. Dept. of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East Box 951569, Los Angeles, CA 90095-1569, USA

Abstract

The rippled sheet was proposed by Pauling and Corey in 1953, yet structural foundation remains extremely limited. Here we report on three X-ray crystal structures of rippled β-sheets, thus providing the long-sought structural basis for the field.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02531K

Reference39 articles.

1. Molecular, Local, and Network-Level Basis for the Enhanced Stiffness of Hydrogel Networks Formed from Coassembled Racemic Peptides: Predictions from Pauling and Corey

2. Enhanced Mechanical Rigidity of Hydrogels Formed from Enantiomeric Peptide Assemblies

3. Rippled β-Sheet Formation by an Amyloid-β Fragment Indicates Expanded Scope of Sequence Space for Enantiomeric β-Sheet Peptide Coassembly