Glucose-nucleobase pairs within DNA: impact of hydrophobicity, alternative linking unit and DNA polymerase nucleotide insertion studies

Author:

Vengut-Climent Empar12345,Peñalver Pablo12345,Lucas Ricardo12345,Gómez-Pinto Irene6378,Aviñó Anna9310118,Muro-Pastor Alicia M.1213148,Galbis Elsa151617188,de Paz M. Violante151617188,Fonseca Guerra Célia1920212223ORCID,Bickelhaupt F. Matthias1920212223ORCID,Eritja Ramón9310118ORCID,González Carlos6378ORCID,Morales Juan Carlos12345ORCID

Affiliation:

1. Department of Biochemistry and Molecular Pharmacology

2. Instituto de Parasitología y Biomedicina López Neyra

3. CSIC

4. PTS Granada

5. Granada

6. Instituto de Química Física ‘Rocasolano’

7. 28006 Madrid

8. Spain

9. Instituto de Química Avanzada de Cataluña (IQAC)

10. CIBER – BBN Networking Centre on Bioengineering, Biomaterials and Nanomedicine

11. E-08034 Barcelona

12. Instituto de Bioquímica Vegetal y Fotosíntesis

13. CSIC – Universidad de Sevilla

14. Sevilla

15. Departamento de Química Orgánica y Farmacéutica

16. Facultad de Farmacia

17. Universidad de Sevilla

18. 41012-Sevilla

19. Department of Theoretical Chemistry

20. Amsterdam Center for Multiscale Modeling

21. Vrije Universiteit Amsterdam

22. 1081 HV Amsterdam

23. The Netherlands

Abstract

Glucose-nucleobase pairs were designed, synthesized and incorporated into duplex DNA. Their stability, structure and polymerase replication was investigated.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Netherlands Organization for Scientific Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Expedient synthesis of l-heptose derived septacidin building blocks from l-glucose;Carbohydrate Research;2023-12

2. Bst polymerase — a humble relative of Taq polymerase;Computational and Structural Biotechnology Journal;2023

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