A multimodal imaging-guided nanoreactor for cooperative combination of tumor starvation and multiple mechanism-enhanced mild temperature phototherapy

Author:

Cao Jin1234,Qiao Bin1234,Luo Yuanli1234,Cheng Chongqing5674,Yang Anyu1234ORCID,Wang Mengzhu8234ORCID,Yuan Xun92104,Fan Kui112104,Li Maoping5674,Wang Zhigang1234ORCID

Affiliation:

1. Institute of Ultrasound Imaging

2. the Second Affiliated Hospital of Chongqing Medical University

3. Chongqing

4. China

5. Department of Ultrasound

6. The First Affiliated Hospital of Chongqing Medical University

7. Chongqing 400042

8. Department of Oncology

9. Department of Ophthalmology

10. Chongqing 400010

11. Department of Nephrology

Abstract

A unique nanoreactor Fe-PDAP/GOx/ICG is engineered to realize starvation therapy and enhanced phototherapy via multilevel mechanisms for simultaneous glucose consumption, oxygen supply, glutathione (GSH) depletion, and heat-resistance relief.

Funder

National Natural Science Foundation of China

Key Project of Application Development Plan of Chongqing City

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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