Cefiderocol susceptibility endows hope in treating carbapenem-resistant Pseudomonas aeruginosa: insights from in vitro and in silico evidence-Reference-Cited by-同舟云学术

Cefiderocol susceptibility endows hope in treating carbapenem-resistant Pseudomonas aeruginosa: insights from in vitro and in silico evidence

Published:2024 Issue:30 Volume:14 Page:21328-21341
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Basu Soumya¹²^ORCID,Ashok Gayathri³^ORCID,Ghosh Soumyadip³^ORCID,Ramaiah Sudha³^ORCID,Veeraraghavan Balaji⁴^ORCID,Anbarasu Anand¹⁵^ORCID

Affiliation:

1. Medical and Biological Computing Laboratory, School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, India

2. Department of Biotechnology, NIST University, Berhampur-761008, India

3. Department of Biosciences, SBST, VIT, Vellore, India

4. Department of Clinical Microbiology, Christian Medical College (CMC), Vellore, India

5. Department of Biotechnology, SBST, VIT, Vellore, India

Abstract

Clinical carbapenemase-positive Pseudomonas aeruginosa strains showing pan-β-lactam resistance had stabilizing mutations in penicillin-binding protein-3. Cefiderocol however showed efficacy with low MIC-values due to multi-target specificity.

Funder

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA04302B

Reference53 articles.

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2. Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Infections

3. Centers for Disease Control and Prevention , Pseudomonas aeruginosa in Healthcare Settings , 2024 , Available at: https://www.cdc.gov/healthcare-associated-infections/

4. Management of ventilator-associated pneumonia: epidemiology, diagnosis and antimicrobial therapy

5. Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone

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