Single-cell multi-element analysis reveals element distribution pattern in human sperm

Author:

Tian Xiangwei123ORCID,Li Xun4,Liu Nian5,Cui Wenbin6,Zheng Lingna7,Guo Yingying12,Liu Yanwei12,Hu Ligang2ORCID,Wang Meng7ORCID,Liang Yong8ORCID,Yin Yongguang1235ORCID,Cai Yong129,Jiang Guibin2,Jin Lei4

Affiliation:

1. Laboratory of Environmental Nanotechnology and Health Effect, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

2. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

5. Institute of Environment and Health, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China

6. R&D Center, Shandong Yingsheng Biotechnology Co., Ltd, Beijing 100088, China

7. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China

8. School of Environment and Health, Jianghan University, Wuhan 430056, China

9. Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, USA

Abstract

We report a novel analytical procedure to simultaneously quantify multiple elements of individual sperm cells. The multi-dimension data can reveal cellular heterogeneity and distribution patterns for the elements.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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