Light-activated controlled release of camptothecin by engineering porous materials: the ship in a bottle concept in drug delivery

Author:

Rivero-Buceta Eva1ORCID,Encheva Mirela E.2ORCID,Cech Bradley3ORCID,Fernandez Eduardo2,Sastre Germán1ORCID,Landry Christopher C.3,Botella Pablo1ORCID

Affiliation:

1. Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos s/n, 46022 Valencia, Spain

2. Institute of Bioengineering, Universidad Miguel Hernández, Elche, Spain and Centre for Network Biomedical Research (CIBER-BBN), Avenida de la Universidad s/n, 03202 Elche, Spain

3. Department of Chemistry, University of Vermont, 82 University Place, Burlington, VT 05405, USA

Abstract

The "ship in a bottle" principle applied to drug delivery. A photoswitchable prodrug is endowed in tailored-pore mesoporous silica nanoparticles. Drug loading and release is controlled by photoisomerization.

Funder

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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