Triptolide: reflections on two decades of research and prospects for the future-Reference-Cited by-同舟云学术

Triptolide: reflections on two decades of research and prospects for the future

Published:2021 Issue:4 Volume:38 Page:843-860
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Tong Lu¹²³⁴⁵,Zhao Qunfei¹²³⁴⁵,Datan Emmanuel⁶⁷⁸⁹,Lin Guo-Qiang¹²³⁴⁵,Minn Il¹⁰⁷⁸⁹,Pomper Martin G.¹⁰⁷⁸⁹,Yu Biao¹¹¹²¹³¹⁴¹⁵,Romo Daniel¹⁶¹⁷¹⁸¹⁹⁹^ORCID,He Qing-Li¹²³⁴⁵,Liu Jun O.⁶⁷⁸⁹^ORCID

Affiliation:

1. The Research Center of Chiral Drugs

2. Innovation Research Institute of Traditional Chinese Medicine

3. Shanghai University of Traditional Chinese Medicine

4. Shanghai 201203

5. China

6. Department of Pharmacology

7. Johns Hopkins School of Medicine

8. Baltimore

9. USA

10. Russell H. Morgan Department of Radiology and Radiological Science

11. State Key Laboratory of Bio-organic and Natural Products Chemistry

12. Center for Excellence in Molecular Synthesis

13. Shanghai Institute of Organic Chemistry

14. University of Chinese Academy of Sciences

15. Chinese Academy of Sciences

16. Department of Chemistry and Biochemistry

17. The CPRIT Synthesis and Drug Lead Discovery Laboratory

18. Baylor University

19. Waco

Abstract

This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide from a Chinese medicinal herb, along with some prospects for the future course of development of triptolide.

Funder

National Natural Science Foundation of China

Flight Attendant Medical Research Institute

Science and Technology Commission of Shanghai Municipality

State Key Laboratory of Bio-organic and Natural Products Chemistry

Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NP/D0NP00054J