Evaluating the impact of systematic hydrophobic modification of model drugs on the control, stability and loading of lipid-based nanoparticles-Reference-Cited by-同舟云学术

Evaluating the impact of systematic hydrophobic modification of model drugs on the control, stability and loading of lipid-based nanoparticles

Published:2021 Issue:48 Volume:9 Page:9874-9884
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Hogarth Cameron¹,Arnold Keith¹,McLauchlin Andrew¹,Rannard Steve P.¹^ORCID,Siccardi Marco²,McDonald Tom O.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK

2. Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK

Abstract

An investigation of how the LogP value of an active controls the formation of lipid-based nanoparticles. Hydrophobically-modified drug analogues were formulated to give nanoparticles with much higher drug loadings than conventional lipid nanocarriers.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2021/TB/D1TB02297K

Reference31 articles.

1. Drug delivery strategies for poorly water-soluble drugs

2. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

3. Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment