Discovery of a lagriamide polyketide by integrated genome mining, isotopic labeling, and untargeted metabolomics-Reference-Cited by-同舟云学术

Discovery of a lagriamide polyketide by integrated genome mining, isotopic labeling, and untargeted metabolomics

Published:2024 Issue:21 Volume:15 Page:8089-8096
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Fergusson Claire H.¹,Saulog Julia¹,Paulo Bruno S.²,Wilson Darryl M.¹,Liu Dennis Y.¹,Morehouse Nicholas J.³,Waterworth Samantha⁴,Barkei John⁴,Gray Christopher A.³,Kwan Jason C.⁴^ORCID,Eustaquio Alessandra S.²^ORCID,Linington Roger G.¹^ORCID

Affiliation:

1. Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada

2. Department of Pharmaceutical Sciences and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA

3. Department of Biological Sciences, University of New Brunswick, Saint John, NB, Canada

4. Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin, Madison, WI, 53705, USA

Abstract

Whole genome sequencing of a Burkholderiales strain library led to the discovery of the antifungal polyketide lagriamide B. Combining data from the genome sequence, NMR experiments and computational predictions defined the full absolute configuration.

Funder

Natural Sciences and Engineering Research Council of Canada

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00825A

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