Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands-Reference-Cited by-同舟云学术

Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands

Published:2021 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Petronilho Elaine C.¹²³⁴⁵,Pedrote Murilo M.¹²³⁴⁵,Marques Mayra A.¹²³⁴⁵^ORCID,Passos Yulli M.⁶⁴⁷⁸,Mota Michelle F.¹²³⁴⁵,Jakobus Benjamin⁹¹⁰⁸,Sousa Gileno dos Santos de¹²³⁴⁵,Pereira da Costa Filipe¹²³⁴⁵,Felix Adriani L.¹²³⁴⁵,Ferretti Giulia D. S.¹²³⁴⁵,Almeida Fernando P.¹¹⁴⁵⁸^ORCID,Cordeiro Yraima⁶⁴⁷⁸^ORCID,Vieira Tuane C. R. G.¹²³⁴⁵^ORCID,de Oliveira Guilherme A. P.¹²³⁴⁵^ORCID,Silva Jerson L.¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Medical Biochemistry Leopoldo de Meis

2. National Institute of Science and Technology for Structural Biology and Bioimaging

3. National Center of Nuclear Magnetic Resonance Jiri Jonas

4. Federal University of Rio de Janeiro

5. Rio de Janeiro RJ 21941-902

6. Faculty of Pharmacy

7. Rio de Janeiro

8. Brazil

9. Modal Informática Ltda

10. Rio de Janeiro RJ 22741-140

11. National Center for Structural Biology and Bioimaging (CENABIO)

Abstract

Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF).

Funder

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Pew Charitable Trusts

Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01739J

Reference71 articles.