Distinct CPT-induced deaths in lung cancer cells caused by clathrin-mediated internalization of CP micelles-Reference-Cited by-同舟云学术

Distinct CPT-induced deaths in lung cancer cells caused by clathrin-mediated internalization of CP micelles

Published:2016 Issue:6 Volume:8 Page:3510-3522
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Liu Yu-Sheng¹²³⁴⁵,Cheng Ru-You⁴⁵²³,Lo Yu-Lun⁴⁵²³,Hsu Chin⁶⁷⁸²³,Chen Su-Hwei¹²³,Chiu Chien-Chih⁹⁵²³,Wang Li-Fang⁴⁵²³¹⁰

Affiliation:

1. School of Pharmacy

2. Kaohsiung Medical University

3. Kaohsiung 807, Taiwan

4. Department of Medicinal and Applied Chemistry

5. College of Life Science

6. Department of Physiology

7. Faculty of Medicine

8. College of Medicine

9. Department of Biotechnology

10. Institute of Medical Science and Technology

Abstract

A chondroitin sulfate-graft-poly(ε-caprolactone), CP, was synthesized to encapsulate camptothecin (micelle/CPT) for tumor-targeting delivery. The therapeutic outcome of the micelle/CPT depends on internalization pathways and cell cycle arrest.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2016/NR/C5NR08345A

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