Visualizing nitroreductase activity in living cells and tissues under hypoxia and hepatic inflammation-Reference-Cited by-同舟云学术

Visualizing nitroreductase activity in living cells and tissues under hypoxia and hepatic inflammation

Published:2022 Issue:7 Volume:147 Page:1449-1456
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Wang Wei¹,Cai Jiexuan¹,Wong Nai-Kei²^ORCID,Hong Meijing¹,Deng Jianbin¹^ORCID,Jin Long¹,Ran Yang¹,Zhang Yi³^ORCID,Zhou Yaqi⁴,Guan Bai-Ou¹

Affiliation:

1. Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communication, Institute of Photonics Technology, Jinan University, Guangzhou 511443, China

2. Clinical Pharmacology Section, Department of Pharmacology, Shantou University Medical College, Shantou 515041, China

3. College of Life Science and Technology, Jinan University, Guangzhou 510632, China

4. Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China

Abstract

An RGD modified water-soluble fluorophore probe was presented for detecting nitroreductase (NTR). The probe showed a remarkable fluorescence “turn-on” signal in the presence of NTR under hypoxia in tumor cells and a hepatitis model.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Guangdong Provincial Pearl River Talents Program

Guangzhou Municipal Science and Technology Project

Guangdong Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/AN/D1AN01724A