Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy-Reference-Cited by-同舟云学术

Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy

Published:2022 Issue:23 Volume:22 Page:4574-4592
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Richardson Lauren S.¹^ORCID,K. Kammala Ananth¹^ORCID,Costantine Maged M.²,Fortunato Stephen J.³,Radnaa Enkhtuya¹^ORCID,Kim Sungjin⁴,Taylor Robert N.⁵,Han Arum⁴^ORCID,Menon Ramkumar¹

Affiliation:

1. Division of Basic and Translational Research, Department of Obstetrics and Gynecology, Division of Basic Science and Translational Medicine, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555-1062, Texas, USA

2. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

3. Obstetrics and Gynecology, Maternal-Fetal Medicine, Ochsner Medical Center, New Orleans, LA, USA

4. Department of Electrical and Computer Engineering, Department of Biomedical Engineering, Texas A&M University, College Station, Texas, USA

5. Department of Obstetrics and Gynecology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, New York, USA

Abstract

We developed multiple microfluidic organ-on-chip (OOC) devices that represent the structure, functions, and responses of the two feto-maternal interfaces (FMis) in humans (fetal membrane [FMi-OOC] and placenta [PLA-OOC]). Generated by BioRender.

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D2LC00691J

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