A forskolin-conjugated insulin analog targeting endogenous glucose-transporter for glucose-responsive insulin delivery-Reference-Cited by-同舟云学术

A forskolin-conjugated insulin analog targeting endogenous glucose-transporter for glucose-responsive insulin delivery

Published:2019 Issue:11 Volume:7 Page:4508-4513
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Wang Jinqiang¹²³⁴⁵,Wang Zejun¹²³⁴⁵^ORCID,Yu Jicheng⁶⁷⁸⁴,Zhang Yuqi⁶⁷⁸⁴,Zeng Yi¹²³⁴⁵,Gu Zhen¹²³⁴⁵^ORCID

Affiliation:

1. Department of Bioengineering

2. University of California

3. Los Angeles

4. USA

5. California NanoSystems Institute

6. Joint Department of Biomedical Engineering

7. University of North Carolina at Chapel Hill and North Carolina State University

8. Raleigh

Abstract

A new insulin analog has been obtained by modifying insulin with forskolin (designated as insulin-F), a glucose transporter (Glut) inhibitor. Insulin-F is capable of binding to Glut on the plasma membrane in a glucose-dependent manner.

Funder

National Institutes of Health

JDRF

University of California, Los Angeles

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/BM/C9BM01283D

Reference37 articles.

1. WHO Global report on diabetes: A summary

2. Advances in transdermal insulin delivery

3. Insulins today and beyond

4. Hypoglycemia in Diabetes

5. Acute effects on insulin sensitivity and diurnal metabolic profiles of a high-sucrose compared with a high-starch diet

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