A triple chain polycationic peptide-mimicking amphiphile – efficient DNA-transfer without co-lipids

Author:

Pinnapireddy Shashank Reddy1234ORCID,Giselbrecht Julia56784,Strehlow Boris1234,Janich Christopher1234,Husteden Catharina56784,Meister Annette59104,Loppnow Harald111284ORCID,Sedding Daniel111284,Erdmann Frank561384ORCID,Hause Gerd514104ORCID,Brezesinski Gerald15164ORCID,Groth Thomas561784ORCID,Langner Andreas56784,Bakowsky Udo1234ORCID,Wölk Christian56784ORCID

Affiliation:

1. Department of Pharmaceutics and Biopharmaceutics

2. University of Marburg

3. Marburg

4. Germany

5. Martin Luther University Halle-Wittenberg

6. Institute of Pharmacy

7. Department of Medicinal Chemistry

8. 06120 Halle (Saale)

9. Institute of Biochemistry and Biotechnology

10. 06120 Halle

11. Medical Faculty of Martin Luther University Halle-Wittenberg

12. Internal Medicine III

13. Department of Pharmacology

14. Biocenter

15. Max Planck Institute of Colloids and Interfaces

16. 14476 Potsdam

17. Department Biomedical Materials

Abstract

DiTT4 lipoplexes have exhibited excellent transfection efficiency in a complex tissue together with a biocompatibility profile that makes it a prospective vehicle for gene delivery.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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