Protein conformational ensembles in function: roles and mechanisms-Reference-Cited by-同舟云学术

Protein conformational ensembles in function: roles and mechanisms

Published:2023 Issue:11 Volume:4 Page:850-864
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Nussinov Ruth¹²³^ORCID,Liu Yonglan³,Zhang Wengang³,Jang Hyunbum¹³^ORCID

Affiliation:

1. Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA

2. Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

3. Cancer Innovation Laboratory, National Cancer Institute, Frederick, MD 21702, USA

Abstract

Protein conformational ensembles determine function: the most aggressive oncogenic K-Ras4B G12V mutant shifts the ensemble to the active state even when GDP-bound.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00114H

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