Traceless β-mercaptan-assisted activation of valinyl benzimidazolinones in peptide ligations-Reference-Cited by-同舟云学术

Traceless β-mercaptan-assisted activation of valinyl benzimidazolinones in peptide ligations

Published:2018 Issue:7 Volume:9 Page:1940-1946
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Yinglu¹²³⁴⁵,Han Lin¹²³⁴⁵,Yuan Ning¹²³⁴⁵,Wang Hanxuan¹²³⁴⁵,Li Hongxing¹²³⁴⁵,Liu Jinrong¹²³⁴⁵,Chen Huan⁶⁷⁸⁹,Zhang Qiang⁶⁷⁸⁹^ORCID,Dong Suwei¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs

2. Department of Chemical Biology

3. School of Pharmaceutical Sciences

4. Peking University

5. Beijing 100191

6. Department of Chemistry

7. University at Albany

8. Albany

9. USA

Abstract

An internal activation strategy-enabled traceless ligation at sterically hindered Val-Xaa site is accomplished under thiol additive-free conditions assisted by a β-mercaptan on the C-terminal valine residue.

Funder

National Natural Science Foundation of China

National Science Foundation

University at Albany

Research Foundation for the State University of New York

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC04148A

Reference80 articles.