An unexpected reversal in the pharmacological stereoselectivity of benzothiadiazine AMPA positive allosteric modulators-Reference-Cited by-同舟云学术

An unexpected reversal in the pharmacological stereoselectivity of benzothiadiazine AMPA positive allosteric modulators

Published:2016 Issue:12 Volume:7 Page:2410-2417
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Battisti Umberto M.¹²³⁴⁵,Citti Cinzia⁶⁷⁸⁴⁹,Rastelli Giulio¹²³⁴,Pinzi Luca¹²³⁴,Puja Giulia¹²³⁴,Ravazzini Federica¹²³⁴,Ciccarella Giuseppe⁶⁷⁸⁴⁹^ORCID,Braghiroli Daniela¹²³⁴,Cannazza Giuseppe¹²³⁴⁹

Affiliation:

1. Department of Life Sciences

2. University of Modena & Reggio Emilia

3. 41125 Modena

4. Italy

5. Department of Medicinal Chemistry

6. Department of Biological and Environmental Sciences and Technologies

7. University of Salento

8. 73100 Lecce

9. CNR-NANOTEC

Abstract

The stereodiscrimination process in the binding of the R isomer with the receptor pocket is ruled by van der Waals interactions and/or H-bonding with water molecules.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00440G

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