Carbon nanotubes as nanovectors for intracellular delivery of laronidase in Mucopolysaccharidosis type I

Author:

Da Ros T.12345,Ostric A.12345,Andreola F.6785,Filocamo M.910115,Pietrogrande M.12135,Corsolini F.910115,Stroppiano M.910115,Bruni S.145,Serafino A.6785,Fiorito S.6785

Affiliation:

1. INSTM unit of Trieste

2. Department of Chemical and Pharmaceutical Sciences

3. University of Trieste

4. 34127 Trieste

5. Italy

6. Institute of Translational Pharmacology

7. CNR

8. 00133 Rome

9. Centro di Diagnostica Genetica e Biochimica delle Malattie Metaboliche

10. Istituto G. Gaslini

11. 16147 Genova

12. Department of Health Sciences

13. Milano University

14. Sanofi Genzyme

Abstract

The first example of intracellular delivery of a therapeutic enzyme by means of CNTs, retaining its activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Reference54 articles.

1. E. F. Neufeld and J.Muenzer , The mucopolysaccharidoses, in The metabolic and molecular bases of inherited disease , ed. C. R. Scriver , A. L. Beaudet , W. S. Sly and D. Valle , McGraw-Hill , New York , 7th edn, 1995 , pp. 2465–2494

2. Mucopolysaccharidoses

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