Sulfasalazine in ionic liquid form with improved solubility and exposure-Reference-Cited by-同舟云学术

Sulfasalazine in ionic liquid form with improved solubility and exposure

Published:2015 Issue:10 Volume:6 Page:1837-1841
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Shadid M.¹²³⁴,Gurau G.⁵⁶⁷⁴⁸,Shamshina J. L.⁵⁶⁷⁴⁸,Chuang B.-C.¹²³⁴,Hailu S.⁹²³⁴,Guan E.¹⁰²³⁴,Chowdhury S. K.¹²³⁴,Wu J.-T.¹²³⁴,Rizvi S. A. A.¹¹¹²¹³¹⁴⁴,Griffin R. J.¹²³⁴,Rogers R. D.⁵⁶⁷⁴⁵

Affiliation:

1. Drug Metabolism and Pharmacokinetics

2. Takeda Pharmaceuticals International Co.

3. Cambridge

4. USA

5. Department of Chemistry

6. The University of Alabama

7. Tuscaloosa

8. 525 Solutions, Inc

9. Pharmaceutical Profiling

10. Drug Safety Evaluation

11. Department of Pharmaceutical Sciences

12. College of Pharmacy

13. Nova Southeastern University

14. Fort Lauderdale

Abstract

An ionic liquid form of sulfasalazine demonstrates improved solubility (4000×), bioavailability (2.5×), andin vivoexposure over the neutral drug.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00290G

Reference36 articles.

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5. Procainium Acetate Versus Procainium Acetate Dihydrate: Irreversible Crystallization of a Room-Temperature Active Pharmaceutical-Ingredient Ionic Liquid upon Hydration

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