Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice-Reference-Cited by-同舟云学术

Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice

Published:2021 Issue:5 Volume:12 Page:2075-2089
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Chen Ximiao¹²³⁴¹,Huang Chongan¹²³⁴⁵,Sun Haiqiu⁶⁷³⁴,Hong Haofeng¹²³⁴⁸,Jin Jie¹²³⁴⁵,Bei Chaoyong¹⁹¹⁰⁴,Lu Zhongqiu¹¹⁷³⁴,Zhang Xiaolei¹²³⁴⁵^ORCID

Affiliation:

1. Department of Orthopaedics

2. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

3. Wenzhou

4. China

5. Zhejiang Provincial Key Laboratory of Orthopaedics

6. Department of Otolaryngology

7. The First Affiliated Hospital of Wenzhou Medical University

8. The Second School of Medicine

9. Affiliated Hospital of Guilin Medical College

10. Guilin

11. Department of Emergency

Abstract

Puerarin suppresses the NF-κB signaling pathway by activating the Nrf2/HO-1 axis, thereby inhibiting IL-1β-induced inflammation and ECM degradation in Osteoarthritis.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Wenzhou Municipal Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D0FO03076G

Reference43 articles.

1. Osteoarthritis

2. Risk factors for the incidence and progression of radiographic knee osteoarthritis

3. Matrix Metalloproteinases: Role In Arthritis

4. Role of interleukin-1 and tumor necrosis factor ? in matrix degradation of human osteoarthritic cartilage

5. An Aggrecanase and Osteoarthritis

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