Two-component boronic acid catalysis for increased reactivity in challenging Friedel–Crafts alkylations with deactivated benzylic alcohols
Author:
Affiliation:
1. Department of Chemistry
2. Centennial Centre for Interdisciplinary Science
3. University of Alberta
4. Edmonton
5. Canada
Abstract
The combination of a boronic acid catalyst with perfluoropinacol as a co-catalyst improves the scope of Friedel–Crafts benzylations of arenes with electronically deactivated primary and secondary benzylic alcohols.
Funder
Natural Sciences and Engineering Research Council of Canada
University of Alberta
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01043B
Reference48 articles.
1. E. J. Ariëns , in Drug Design: Medicinal Chemistry: A Series of Monographs , Elsevier , 2013 , vol. 4
2. Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview
3. Lasofoxifene: a third-generation selective estrogen receptor modulator for the prevention and treatment of osteoporosis
4. Tolterodine for the treatment of overactive bladder: a review
5. Pimozide
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