Delineation of the complete reaction cycle of a natural Diels–Alderase-Reference-Cited by-同舟云学术

Delineation of the complete reaction cycle of a natural Diels–Alderase

Published:2024 Issue:29 Volume:15 Page:11572-11583
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Maschio Laurence¹,Back Catherine R.¹,Alnawah Jawaher²³^ORCID,Bowen James I.²^ORCID,Johns Samuel T.¹,Mbatha Sbusisiwe Z.²,Han Li-Chen²,Lees Nicholas R.²,Zorn Katja⁴,Stach James E. M.⁵^ORCID,Hayes Martin A.⁴^ORCID,van der Kamp Marc W.¹^ORCID,Pudney Christopher R.⁶,Burston Steven G.¹^ORCID,Willis Christine L.²^ORCID,Race Paul R.⁵^ORCID

Affiliation:

1. School of Biochemistry, University Walk, University of Bristol, BS8 1TD, UK

2. School of Chemistry, University of Bristol, Cantock's Close, BS8 1TS, UK

3. Department of Chemistry, King Faisal University, College of Science, Al-Ahsa 31982, Saudi Arabia

4. Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83 Mölndal, Sweden

5. School of Natural and Environmental Sciences, Newcastle University, NE1 7RU, UK

6. Department of Biology and Biochemistry, University of Bath, Claverton Down, BA2 7AY, UK

Abstract

A molecular description of the complete reaction cycle of the bona fide natural Diels–Alderase AbyU is presented, revealing the mechanistic intricacies of this enzyme system.

Funder

Engineering and Physical Sciences Research Council

Deanship of Scientific Research, King Faisal University

Biotechnology and Biological Sciences Research Council

AstraZeneca

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC02908A

Reference50 articles.

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4. Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue

5. Abyssomicin Biosynthesis: Formation of an Unusual Polyketide, Antibiotic-Feeding Studies and Genetic Analysis

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