Self-assembling Nanoarchitectonics for Oral Drug Delivery

Abstract

Orally taken drugs are dissolved in gastrointestinal tract, followed by their absorption mainly from the small intestinal walls. However, many drugs experience problems during this process, which may lead to an insufficient therapeutic effect of the drug. This may be overcome by the concept of self-assembling nanoarchitectonics. Well-designed formulations which may include surfactant and polymers enables the spontaneous formation of nanoarchitectures in the small intestine to aid the absorption process of drug molecules. In this chapter, features and detailed action mechanisms of self-assemble nanoarchitectures composed of drug and other molecules are discussed for enabling the design of an effective oral drug delivery system.