An <i>in vitro</i> investigation of the hepatic toxicity of PEGylated polymeric redox responsive nanoparticles-Reference-Cited by-同舟云学术

An in vitro investigation of the hepatic toxicity of PEGylated polymeric redox responsive nanoparticles

Published:2022 Issue:20 Volume:12 Page:12860-12870
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Powell Leagh G.¹,Alexander Cameron²^ORCID,Stone Vicki¹,Johnston Helinor J.¹,Conte Claudia³^ORCID

Affiliation:

1. Nano Safety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University, UK

2. Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, UK

3. Department of Pharmacy, University of Naples, Naples, Italy

Abstract

PEGylated polymeric RR-NPs are less toxic than nRR-NPs. Both formulations did not have a negative impact on cell viability, but were able to elicit sub-lethal toxicity, especially in the case of non redox responsive NPs.

Funder

Engineering and Physical Sciences Research Council

Associazione Italiana per la Ricerca sul Cancro

Marie Curie

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA00395C

Reference35 articles.

1. Polymeric nanoparticles for cancer therapy

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3. Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments

4. PEGylation: a promising strategy to overcome challenges to cancer-targeted nanomedicines: a review of challenges to clinical transition and promising resolution

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