Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/pDNA nanoparticles in ovarian cancer-Reference-Cited by-同舟云学术

Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/pDNA nanoparticles in ovarian cancer

Published:2021 Issue:34 Volume:13 Page:14538-14551
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Sun Zhe¹,Huang Jinhai¹^ORCID,Su Linjia²,Li Jing²,Qi Fangzheng²,Su Huishan²,Chen Yanan²,Zhang Qing³,Zhang Qiangzhe⁴,Li Zongjin²^ORCID,Zhang Sihe²^ORCID

Affiliation:

1. School of Life Sciences, Tianjin University, Weijin Road 92, Tianjin 300072, China

2. School of Medicine, Nankai University, Tianjin, P.R. China

3. Cancer Hospital of Tianjin Medical University, Tianjin, P.R. China

4. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300350, China

Abstract

The cellular uptake of C16TAB-condensed Tat/pDNA nanoparticles (Tat/pDNA/C16TAB, T–P–C) was controlled by Arf6-dependent, Rab-activated macropinocytosis, which promoted T–P–C nanoparticle-based suicide gene therapy of ovarian cancer.

Funder

Chinese Pharmaceutical Association

Nankai University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR03974A

Reference49 articles.

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2. Ovarian carcinosarcoma: Current developments and future perspectives