The SPL7013 dendrimer destabilizes the HIV-1 gp120–CD4 complex-Reference-Cited by-同舟云学术

The SPL7013 dendrimer destabilizes the HIV-1 gp120–CD4 complex

Published:2015 Issue:44 Volume:7 Page:18628-18641
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Nandy Bidisha¹²³⁴,Saurabh Suman¹²³⁴,Sahoo Anil Kumar¹²³⁴,Dixit Narendra M.⁵³⁴⁶³,Maiti Prabal K.¹²³⁴

Affiliation:

1. Center for Condensed Matter Theory

2. Department of Physics

3. Indian Institute of Science

4. Bangalore, India

5. Department of Chemical Engineering

6. Centre for Biosystems Science and Engineering

Abstract

Steered MD and equilibrium energy calculations reveal that the SPL7013 dendrimer destabilizes the gp120–CD4 complex, potentially explaining its anti-HIV-1 activity.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2015/NR/C5NR04632G

Reference43 articles.

1. A Phase I Randomized Placebo Controlled Trial of the Safety of 3% SPL7013 Gel (VivaGel®) in Healthy Young Women Administered Twice Daily for 14 Days

2. Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004)

3. Polyanionic carbosilane dendrimer-conjugated antiviral drugs as efficient microbicides: Recent trends and developments in HIV treatment/therapy

4. Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications

5. Dendrimers as topical microbicides with activity against HIV

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