A mimotope attached to an ITIM–SHP-1 interaction inhibitory peptide boosts immune response and efficacy-Reference-Cited by-同舟云学术

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A mimotope attached to an ITIM–SHP-1 interaction inhibitory peptide boosts immune response and efficacy

Published:2021 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Roy Koushik¹²³⁴,Roy Syamal⁵²³⁴,Roy Siddhartha⁶⁷⁸⁴^ORCID

Affiliation:

1. Division of Structural Biology and Bioinformatics

2. CSIR-Indian Institute of Chemical Biology

3. Kolkata 700032

4. India

5. Infectious Diseases and Immunology Division

6. Department of Biophysics

7. Bose Institute

8. Kolkata

Abstract

Conformationally-constrained antigen is more immunogenic and attenuation of inhibitory Fc receptor by ITIM mimicking peptide enhance antibody production to a defined peptide antigen.

Funder

Council of Scientific and Industrial Research

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00099C

Reference26 articles.

1. More than one reason to rethink the use of peptides in vaccine design

2. Peptide-Based Vaccines: Current Progress and Future Challenges

3. Trial to evaluate the immunogenicity and safety of a melanoma helper peptide vaccine plus incomplete Freund’s adjuvant, cyclophosphamide, and polyICLC (Mel63)

4. Early phase II study of mixed 19‐peptide vaccine monotherapy for refractory triple‐negative breast cancer

5. Peptide-based synthetic vaccines

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