One-pot synthesis of 2-hydroxymethylindoles via photoredox-catalyzed ketyl–ynamide coupling/1,3-allylic alcohol transposition-Reference-Cited by-同舟云学术

One-pot synthesis of 2-hydroxymethylindoles via photoredox-catalyzed ketyl–ynamide coupling/1,3-allylic alcohol transposition

Published:2020 Issue:14 Volume:22 Page:4483-4488
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Wang Ze-Shu¹²³⁴⁵,Chen Yang-Bo¹²³⁴⁵,Wang Kun¹²³⁴⁵,Xu Zhou⁶⁷⁸⁹⁵^ORCID,Ye Long-Wu¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory for Chemical Biology of Fujian Province and State Key Laboratory of Physical Chemistry of Solid Surfaces

2. College of Chemistry and Chemical Engineering

3. Xiamen University

4. Xiamen 361005

5. China

6. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy

7. School of Pharmacy

8. Xuzhou Medical University

9. Xuzhou 221004

Abstract

An efficient photoredox-catalyzed ketyl–ynamide coupling of alkyl sulfonyl substituted ynamides followed by 1,3-allylic alcohol transposition in one-pot has been developed, affording 2-hydroxymethylindoles in generally moderate to good yields.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

Xiamen University

Qinglan Project

Six Talent Peaks Project in Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/GC/D0GC01522A

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