Spatiotemporal neocartilage growth in matrix-metalloproteinase-sensitive poly(ethylene glycol) hydrogels under dynamic compressive loading: an experimental and computational approach-Reference-Cited by-同舟云学术

Spatiotemporal neocartilage growth in matrix-metalloproteinase-sensitive poly(ethylene glycol) hydrogels under dynamic compressive loading: an experimental and computational approach

Published:2020 Issue:14 Volume:8 Page:2775-2791
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Schneider Margaret C.¹²³⁴,Lalitha Sridhar Shankar⁵²³⁴,Vernerey Franck J.⁵²³⁴⁶^ORCID,Bryant Stephanie J.¹²³⁴⁶^ORCID

Affiliation:

1. Department of Chemical and Biological Engineering

2. University of Colorado

3. Boulder

4. USA

5. Department of Mechanical Engineering

6. Materials Science and Engineering Program

Abstract

A combined experimental and computational approach shows rapid ECM growth in cell clusters with load-induced differences impacting the gel to tissue transition.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2020/TB/C9TB02963J

Reference54 articles.

1. Manipulations in hydrogel chemistry control photoencapsulated chondrocyte behavior and their extracellular matrix production

2. Crosslinking Density Influences Chondrocyte Metabolism in Dynamically Loaded Photocrosslinked Poly(ethylene glycol) Hydrogels

3. Nondestructive evaluation of a new hydrolytically degradable and photo-clickable PEG hydrogel for cartilage tissue engineering