Molecularly imprinted polymer nanogels targeting the HAV motif in cadherins inhibit cell–cell adhesion and migration-Reference-Cited by-同舟云学术

Molecularly imprinted polymer nanogels targeting the HAV motif in cadherins inhibit cell–cell adhesion and migration

Published:2022 Issue:35 Volume:10 Page:6688-6697
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Medina Rangel Paulina X.¹,Mier Alejandra¹,Moroni Elena¹,Merlier Franck¹,Gheber Levi A.²,Vago Razi²,Maffucci Irene¹^ORCID,Tse Sum Bui Bernadette¹^ORCID,Haupt Karsten¹^ORCID

Affiliation:

1. CNRS Enzyme and Cell Engineering Laboratory, Université de Technologie de Compiègne, Rue du Docteur Schweitzer, CS 60319, 60203 Compiègne Cedex, France

2. The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel

Abstract

Molecularly imprinted polymer nanogels (MIPs) as synthetic antibody mimics against the HAVDI epitope of N-cadherin specifically inhibit cell–cell aggregation and tumor cell invasiveness by blocking cadherin-mediated interactions.

Funder

Consejo Nacional de Ciencia y Tecnología

Institut Universitaire de France

European Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB00680D

Reference37 articles.

1. Molecular nature of the calcium-dependent cell-cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibody