Stepwise co-delivery of an enzyme and prodrug based on a multi-responsive nanoplatform for accurate tumor therapy

Author:

Chen Li12345,Liu Zhongning678910,Jin Ronghua12345,Yang Xiaoshan111213145,Bai Yongkang12345,Liu Shiyu111213145,Chen Xin12345ORCID

Affiliation:

1. School of Chemical Engineering and Technology

2. Shaanxi Key Laboratory of Energy Chemical Process Intensification

3. Institute of Polymer Science in Chemical Engineering

4. Xi’an Jiao Tong University

5. Xi’an

6. Department of Prosthodontics

7. Peking University School and Hospital of Stomatology

8. National Engineering Laboratory for Digital and Material Technology of Stomatology

9. Beijing Key Laboratory of Digital Stomatology

10. Beijing 100081

11. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases

12. Center for Tissue Engineering

13. School of Stomatology

14. Fourth Military Medical University

Abstract

We fabricated a HAase@SiO2@prodrug nanoplatform with a core–shell–corona structure for highly selective and effective tumor therapy via microenvironment-responsive sequential catalytic reactions.

Funder

National Natural Science Foundation of China

Xi’an Jiaotong University

Natural Science Foundation of Shaanxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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