Direct regioisomer analysis of crude reaction mixtures via molecular rotational resonance (MRR) spectroscopy-Reference-Cited by-同舟云学术

Direct regioisomer analysis of crude reaction mixtures via molecular rotational resonance (MRR) spectroscopy

Published:2020 Issue:24 Volume:11 Page:6332-6338
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Joyce Leo A.¹²³⁴^ORCID,Schultz Danielle M.¹²³⁴^ORCID,Sherer Edward C.⁵²³⁴^ORCID,Neill Justin L.⁶⁷⁴^ORCID,Sonstrom Reilly E.⁸⁹⁷⁴,Pate Brooks H.⁸⁹⁷⁴

Affiliation:

1. Department of Process Research & Development

2. Merck & Co., Inc.

3. Rahway

4. USA

5. Department of Computational and Structural Chemistry

6. BrightSpec, Inc.

7. Charlottesville

8. Department of Chemistry

9. University of Virginia

Abstract

Direct analyses of crude reaction mixtures have been carried out using molecular rotational resonance (MRR) spectroscopy, allowing identification and quantification of major and minor components without sample purification or reference standards.

Funder

National Science Foundation

Virginia Biosciences Health Research Corporation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC01853H

Reference43 articles.

1. Chromatographic resolution of closely related species: Separation of warfarin and hydroxylated isomers

2. Chromatographic Resolution of Closely Related Species in Pharmaceutical Chemistry: Dehalogenation Impurities and Mixtures of Halogen Isomers

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