A ZnII complex of ornidazole with decreased nitro radical anions that is still highly active on Entamoeba histolytica
Author:
Affiliation:
1. Department of Chemistry (Inorganic Section)
2. Jadavpur University
3. Kolkata – 700 032
4. India
5. Department of Physics
6. School of Environmental Sciences
7. Jawaharlal Nehru University
8. New Delhi – 110 067
Abstract
A monomeric complex of ZnII with ornidazole [Zn(Onz)2Cl2] decreases formation of the nitro-radical anion (R–NO2˙−), and this is realized by recording it in an enzyme assay using xanthine oxidase, which is a model nitro-reductase.
Funder
Department of Science and Technology, Ministry of Science and Technology, India
University Grants Commission
Jadavpur University
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA02597F
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1. Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
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