Mononuclear Pd(ii) and Pt(ii) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media-Reference-Cited by-同舟云学术

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Mononuclear Pd(ii) and Pt(ii) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

Published:2018 Issue:1 Volume:5 Page:73-83
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Matesanz Ana I.¹²³^ORCID,Jimenez-Faraco Eva¹²³^ORCID,Ruiz María C.⁴⁵⁶⁷⁸^ORCID,Balsa Lucia M.⁴⁵⁶⁷⁸^ORCID,Navarro-Ranninger Carmen¹²³^ORCID,León Ignacio E.⁴⁵⁶⁷⁸^ORCID,Quiroga Adoracion G.¹²³^ORCID

Affiliation:

1. Dept. Química Inorgánica and IAdChem (Institute for Advanced Research in Chemical Science) Universidad Autónoma de Madrid

2. 28045 Madrid

3. Spain

4. Centro de Química Inorgánica (CEQUINOR

5. CONICET)

6. Facultad de Ciencias Exactas

7. Universidad Nacional de La Plata

8. 1900 La Plata

Abstract

Pd(ii) and P(ii) thiosemicarbazone complexes with high selectivity towards cancer cells and a novel biological interaction profile.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QI/C7QI00446J

Reference52 articles.

1. Impact of Metal Coordination on Cytotoxicity of 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone (Triapine) and Novel Insights into Terminal Dimethylation

2. Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers

3. Inhibition of ribonucleotide reductase by α-(N)-heterocyclic carboxaldehyde thiosemicarbazones

4. Inhibition of tumor cell transplantability by iron and copper complexes of 5-substituted 2-formylpyridine thiosemicarbazones

5. M.-C. Liu , T.-S.Lin , A. C.Sartorelli , G. P.Ellis and D. K.Luscombe , in Prog Med Chem , Elsevier , 1995 , vol. 32 , pp. 1–35

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