Time-resolved detection of SDS-induced conformational changes in α-synuclein by a micro-stopped-flow system-Reference-Cited by-同舟云学术

Time-resolved detection of SDS-induced conformational changes in α-synuclein by a micro-stopped-flow system

Published:2021 Issue:2 Volume:11 Page:1086-1097
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Takaramoto Shunki¹²³⁴⁵^ORCID,Nakasone Yusuke¹²³⁴⁵,Sadakane Kei⁶⁷⁸⁹⁵,Maruta Shinsaku⁶⁷⁸⁹⁵,Terazima Masahide¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Graduate School of Science

3. Kyoto University

4. Kyoto 606-8502

5. Japan

6. Department of Bioinformatics

7. Graduate School of Engineering

8. Soka University

9. Hachioji

Abstract

Dynamics of conformation changes of α-synuclein induced by the presence of SDS micelles are revealed using time-resolved diffusion, CD, and FRET measurements combined with a micro-stopped flow system.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Research Foundation for Opto-Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA09614H

Reference46 articles.

1. NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

2. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

3. α-Synuclein misfolding and Parkinson's disease

4. α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer

5. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mechanisms of Biomolecular Self‐Assembly Investigated Through In Situ Observations of Structures and Dynamics;Angewandte Chemie;2023-09-13

2. Mechanisms of Biomolecular Self‐Assembly Investigated Through In Situ Observations of Structures and Dynamics;Angewandte Chemie International Edition;2023-09-13

3. Time-Resolved Diffusion Method to Detect and Reveal Protein Reactions Leading to Their Functions;Bulletin of the Chemical Society of Japan;2023-07-25

4. Intrinsically disordered plant protein PARCL colocalizes with RNA in phase-separated condensates whose formation can be regulated by mutating the PLD;Journal of Biological Chemistry;2022-12

5. Revealing protein reactions using transient grating method: Photo-induced heating, volume change, and diffusion change;Journal of Applied Physics;2022-04-14