Time-resolved detection of SDS-induced conformational changes in α-synuclein by a micro-stopped-flow system-Reference-Cited by-同舟云学术

Time-resolved detection of SDS-induced conformational changes in α-synuclein by a micro-stopped-flow system

Published:2021 Issue:2 Volume:11 Page:1086-1097
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Takaramoto Shunki¹²³⁴⁵^ORCID,Nakasone Yusuke¹²³⁴⁵,Sadakane Kei⁶⁷⁸⁹⁵,Maruta Shinsaku⁶⁷⁸⁹⁵,Terazima Masahide¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Graduate School of Science

3. Kyoto University

4. Kyoto 606-8502

5. Japan

6. Department of Bioinformatics

7. Graduate School of Engineering

8. Soka University

9. Hachioji

Abstract

Dynamics of conformation changes of α-synuclein induced by the presence of SDS micelles are revealed using time-resolved diffusion, CD, and FRET measurements combined with a micro-stopped flow system.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Research Foundation for Opto-Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA09614H

Reference46 articles.

1. NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

2. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

3. α-Synuclein misfolding and Parkinson's disease

4. α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer

5. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

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