Synthesis of 1,3-disubstituted bicyclo[1.1.0]butanes via directed bridgehead functionalization-Reference-Cited by-同舟云学术

Synthesis of 1,3-disubstituted bicyclo[1.1.0]butanes via directed bridgehead functionalization

Published:2021 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

McNamee Ryan E.¹²³,Haugland Marius M.¹²³^ORCID,Nugent Jeremy¹²³,Chan Rachel¹²³,Christensen Kirsten E.¹²³,Anderson Edward A.¹²³^ORCID

Affiliation:

1. Chemistry Research Laboratory

2. Oxford

3. UK

Abstract

Bicyclo[1.1.0]butanes (BCBs) are valuable precursors to four-membered rings and bicyclo[1.1.1]pentanes, and useful bioconjugation agents. We describe a versatile approach to access 1,3-disubstituted BCBs, which are otherwise challenging to prepare.

Funder

Engineering and Physical Sciences Research Council

AstraZeneca

Diamond Light Source

Defence Science and Technology Laboratory

GlaxoSmithKline

H2020 Marie Skłodowska-Curie Actions

Novartis

Pfizer

Syngenta International

UCB UK

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01836A

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