SuFEx-enabled, chemoselective synthesis of triflates, triflamides and triflimidates-Reference-Cited by-同舟云学术

SuFEx-enabled, chemoselective synthesis of triflates, triflamides and triflimidates

Published:2022 Issue:8 Volume:13 Page:2270-2279
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Li Bing-Yu¹^ORCID,Voets Lauren¹^ORCID,Van Lommel Ruben¹²^ORCID,Hoppenbrouwers Fien¹^ORCID,Alonso Mercedes²^ORCID,Verhelst Steven H. L.³⁴^ORCID,De Borggraeve Wim M.¹^ORCID,Demaerel Joachim¹³^ORCID

Affiliation:

1. Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Box 2404, 3001 Leuven, Belgium

2. Eenheid Algemene Chemie (ALGC), Department of Chemistry, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium

3. Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, KU Leuven, O&N I bis, Herestraat 49, box 901, 3000 Leuven, Belgium

4. Leibniz Institute for Analytical Sciences ISAS, e.V., Otto-Hahn-Str. 6b, 44227 Dortmund, Germany

Abstract

Triflyl fluoride gas (CF3SO2F) and its aza analogues are reported as new SuFEx activators. These SVI–F reagents react efficiently with a variety of nucleophiles, yet the presence of water grants complete chemoselectivity to phenols.

Funder

KU Leuven

Vrije Universiteit Brussel

Fonds Wetenschappelijk Onderzoek

Herculesstichting

China Scholarship Council

Bundesministerium für Bildung und Forschung

Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry