Anti-cancer activity and mechanism of flurbiprofen organoselenium compound RY-1-92 in non-small cell lung cancer

Author:

Cui Bo1,Cheng Xianda1,Zhang Xin1,Chen Lili123,Pang Wenqian1,Liu Yue1,Yang Zhe1ORCID,Li Hui1,He Xianran4,Li Xiaolong5,Bi Xiuli12ORCID

Affiliation:

1. College of Life Science, Liaoning University, Shenyang, 110036, China

2. Shenyang Key Laboratory of Chronic Disease Occurrence and Nutrition Intervention, College of Life Sciences, Liaoning University, Shenyang, 110036, China

3. College of Mathematics and Statistics, Liaoning University, Shenyang, 110036, China

4. Institute for Interdisciplinary Research, Jianghan University, Wuhan Economic and Technological Development Zone, Wuhan 430056, China

5. Shenzhen Fushan Biological Technology Co., Ltd, Kexing Science Park A1 1005, Nanshan Zone, Shenzhen 518057, China

Abstract

Flurbiprofen organic selenium compound RY-1-92 has anticancer activity in non-small cell lung cancer by targeting TRPV1 and its downstream MAPK signaling.

Funder

China Postdoctoral Science Foundation

Liaoning Revitalization Talents Program

Department of Education of Liaoning Province

Liaoning University

Publisher

Royal Society of Chemistry (RSC)

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