Pregnancy complications and birth outcomes following low-level exposure to per- and polyfluoroalkyl substances in the vitamin D antenatal asthma reduction trial

Author:

Begum Sofina12ORCID,Prince Nicole1,Mínguez-Alarcón Lidia13,Chen Yulu1,Soeteman Djøra I.14,Fangal Vrushali15,Huang Mengna1,Wheelock Craig6,Mendez Kevin1,Litonjua Augusto A.7,Weiss Scott T.1,Lasky-Su Jessica1,Kelly Rachel S.1

Affiliation:

1. Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA

2. Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK

3. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA

4. Center for Health Decision Science, Harvard T. H. Chan School of Public Health, Boston, MA, USA

5. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA

6. Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry 2, Karolinska Institute, Stockholm, Sweden

7. Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA

Abstract

Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic, highly fluorinated aliphatic compounds, commonly utilised in a wide variety of consumer products with diverse applications.

Funder

National Heart, Lung, and Blood Institute

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Reference69 articles.

1. A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects

2. ATSDR , Toxicological Profile for Perfluoroalkyls – Release May 2021 . Agency for Toxic Substances and Disease Registry , 2021 May

3. Organisation for Economic Co-operation and Development , Toward a New Comprehensive Global Database of Per- and Polyfluoroalkyl Substances (PFASs): Summary Report on Updating the OECD 2007 List of Per- and Polyfluoroalkyl Substances (PFASs) , 2018

4. The high persistence of PFAS is sufficient for their management as a chemical class

5. High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples

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