Thermodynamics of cell penetrating peptides on lipid membranes: sequence and membrane acidity regulate surface binding

Author:

Ramírez Pedro G.1234,Del Pópolo Mario G.564ORCID,Vila Jorge A.1234ORCID,Longo Gabriel S.789104ORCID

Affiliation:

1. Instituto de Matemática Aplicada San Luis (IMASL)

2. UNSL-CONICET

3. San Luis

4. Argentina

5. Instituto Interdisciplinario de Ciencias Básicas (ICB-CONICET) & Facultad de Ciencias Exactas y Naturales (FCEN-UNCuyo)

6. Mendoza

7. Instituto de Investigaciones Fisicoquímicas

8. Teóricas y Aplicadas (INIFTA)

9. UNLP-CONICET

10. La Plata

Abstract

Acidic lipids respond to pH in ways that fully promote or deplete the surface accumulation of cell penetrating peptides.

Funder

Fondo para la Investigación Científica y Tecnológica

Consejo Nacional de Investigaciones Científicas y Técnicas

Universidad Nacional de San Luis

Universidad Nacional de Cuyo

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Enhanced Adsorption Response of pH-Sensitive Peptides: The Role of Membrane Acidity;The Journal of Physical Chemistry B;2024-04-26

2. Leaflet-Dependent Effect of Anionic Lipids on Membrane Insertion by Cationic Cell-Penetrating Peptides;The Journal of Physical Chemistry Letters;2023-06-20

3. Cell-Translocation Mechanisms of CPPs;CPP, Cell-Penetrating Peptides;2023

4. The pH gradient in cancer: pH deregulation;pH Deregulation as the Eleventh Hallmark of Cancer;2023

5. Competitive protein adsorption on charge regulating silica-like surfaces: the role of protonation equilibrium;Journal of Physics: Condensed Matter;2022-07-05

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