Multidimensional (3D/4D-QSAR) probability-guided pharmacophore mapping: investigation of activity profile for a series of drug absorption promoters-Reference-Cited by-同舟云学术

Multidimensional (3D/4D-QSAR) probability-guided pharmacophore mapping: investigation of activity profile for a series of drug absorption promoters

Published:2016 Issue:80 Volume:6 Page:76183-76205
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bak A.¹²³⁴⁵,Kozik V.⁶²³⁴⁵,Smolinski A.⁷⁸⁴⁵,Jampilek J.⁹¹⁰¹¹¹²¹³

Affiliation:

1. Department of Organic Chemistry

2. Institute of Chemistry

3. University of Silesia

4. Katowice

5. Poland

6. Department of Synthesis Chemistry

7. Department of Energy Saving and Air Protection

8. Central Mining Institute

9. Department of Pharmaceutical Chemistry

10. Faculty of Pharmacy

11. Comenius University

12. Bratislava

13. Slovakia

Abstract

A hybrid approach that combines 3D and 4D-QSAR methods based on grid and neural paradigms with automated IVE-PLS procedure was examined to identify the pharmacophore pattern for cholic acid derivatives as potential drug absorption promoters.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA15820J

Reference50 articles.

1. Methods for Building QSARs

2. Click Chemistry: Diverse Chemical Function from a Few Good Reactions

3. Structure-Based Modeling of Dye-Fiber Affinity with SOM-4D-QSAR Paradigm: Application to Set of Anthraquinone Derivatives

4. Receptor Dependent Multidimensional QSAR for Modeling Drug - Receptor Interactions

5. Beware of q2!

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