3′-Amino modifications enhance the antifungal properties of <i>N</i><sup>4</sup>-alkyl-5-methylcytidines for potential biocides-Reference-Cited by-同舟云学术

3′-Amino modifications enhance the antifungal properties of N⁴-alkyl-5-methylcytidines for potential biocides

Published:2022 Issue:12 Volume:46 Page:5614-5626
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Alexandrova Liudmila A.¹^ORCID,Shevchenko Oleg V.¹^ORCID,Jasko Maxim V.¹^ORCID,Solyev Pavel N.¹^ORCID,Karpenko Inna L.¹^ORCID,Negrya Sergey D.¹^ORCID,Efremenkova Olga V.²^ORCID,Vasilieva Byazilya F.²^ORCID,Efimenko Tatiana A.²^ORCID,Avdanina Darya A.³^ORCID,Nuraeva Gulgina K.³^ORCID,Potapov Mark P.³^ORCID,Kukushkina Vera I.³^ORCID,Kochetkov Sergey N.¹^ORCID,Zhgun Alexander A.³^ORCID

Affiliation:

1. Engelhardt Institute of Molecular Biology RAS, 32 Vavilova St., 119991 Moscow, Russia

2. Gause Institute of New Antibiotics, 11 Bol'shaya Pirogovskaya St., 119021 Moscow, Russia

3. Research Center of Biotechnology RAS, 33 Leninsky Ave, 119071 Moscow, Russia

Abstract

A set of 3′-modified N4-alkyl-5-methyl-2′-deoxycytidines has been synthesized and evaluated for biological activity. The replacement of the 3′-hydroxyl group with amino, aminoethyl and dialkylamino groups significantly enhances antifungal activity.

Funder

Ministry of Education and Science of the Russian Federation

Russian Foundation for Basic Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ04312A

Reference40 articles.

1. Contribution of the Microbial Communities Detected on an Oil Painting on Canvas to Its Biodeterioration

2. Microbial deterioration of cultural heritage and works of art — tilting at windmills?