Fabrication of hypoxia-responsive and uperconversion nanoparticles-modified RBC micro-vehicles for oxygen delivery and chemotherapy enhancement

Author:

Wang Peiyuan12345,Jiang Suhua12345,Li Yang12345ORCID,Luo Qiang12345,Lin Jinyan12345,Hu Lidan67895,Xu Congjian10115,Zhu Jun1213145,Fan Lingling10115ORCID

Affiliation:

1. Key Laboratory of Design and Assembly of Functional Nanostructures

2. Fujian Institute of Research on the Structure of Matter

3. Chinese Academy of Sciences

4. Fuzhou 350002

5. P. R. China

6. Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study

7. Department of Biochemistry and Molecular Biology

8. University of South China

9. Hengyang 421001

10. Obstetrics and Gynecology Hospital of Fudan University

11. Shanghai 200011

12. Department of Oncology

13. Shanghai Pulmonary Hospital

14. Tongji University School of Medicine

Abstract

RBC based micro-vehicles were successfully fabricated for hypoxia activated O2 precise delivery under 980 nm laser irradiation. Interestingly, owing to hypoxia alleviating, the chemotherapy enhancement of PTX for ovarian tumor was realized.

Funder

National Basic Research Program of China

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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