Irreversible destruction of amyloid fibril plaques by conjugated polymer based fluorogenic nanogrenades

Author:

Dou Wei-Tao1234,Lv Ying56784,Tan Chunyan56784,Chen Guo-Rong1234,He Xiao-Peng1234

Affiliation:

1. Key Laboratory for Advanced Materials & Institute of Fine Chemicals

2. East China University of Science and Technology

3. Shanghai 200237

4. P. R. China

5. The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology

6. the Graduate School at Shenzhen

7. Tsinghua University

8. Shenzhen 518055

Abstract

Supramolecular assembly between conjugated polymers and fluorescent dyes produces a unique class of fluorogenic “nanogrenades” with the ability to image as well as irreversibly destruct amyloid β fibril plaques by simple white-light irradiation.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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