Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem-Reference-Cited by-同舟云学术

Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem

Published:2022 Issue:64 Volume:58 Page:9010-9013
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yue Xiaoping¹,Li Yitong¹,Liu Minjie²³,Sang Di²³,Huang Zedu²³^ORCID,Chen Fener¹²³^ORCID

Affiliation:

1. Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P. R. China

2. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, P. R. China

3. Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, 220 Handan Road, Shanghai, 200433, P. R. China

Abstract

A ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution strategy was developed for the highly stereoselective and green synthesis of anti-aryl α-chloro β-hydroxy esters.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC03102G

Reference24 articles.

1. Microbial reduction of 2-chloro-3-aryl-3-oxopropionic acid esters

2. Microbial Asymmetric Reduction. Preparation of Optically Active Methyl trans-3-(4-Methoxyphenyl)Glycidates

3. Asymmetric Reduction of 2-Chloro-3-oxo Esters by Transfer Hydrogenation

4. Catalytic Approaches to Optically Active 1,5-Benzothiazepines

5. Asymmetric catalysis in synthetic strategies for chiral benzothiazepines

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