Maternal sucralose exposure induces Paneth cell defects and exacerbates gut dysbiosis of progeny mice-Reference-Cited by-同舟云学术

Maternal sucralose exposure induces Paneth cell defects and exacerbates gut dysbiosis of progeny mice

Published:2021 Issue:24 Volume:12 Page:12634-12646
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Dai Xin¹,Wang Chen¹,Guo Zixuan¹,Li Yun²,Liu Tianyu¹,Jin Ge¹,Wang Sinan¹,Wang Bangmao¹,Jiang Kui¹,Cao Hailong¹^ORCID

Affiliation:

1. Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China

2. Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China

Abstract

Research has shown that maternal sucralose (MS) exposure alters the gut microbiota of offspring at weaning and predisposes the offspring to developing obesity, non-alcoholic fatty liver disease and metabolic syndrome later in life.

Funder

National Natural Science Foundation of China

Tianjin Science and Technology Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO02921E

Reference50 articles.

1. Biological fate of low-calorie sweeteners

2. The role of low-calorie sweeteners in the prevention and management of overweight and obesity: evidence v. conjecture