Regioselective ortho halogenation of N-aryl amides and ureas via oxidative halodeboronation: harnessing boron reactivity for efficient C–halogen bond installation-Reference-Cited by-同舟云学术

Regioselective ortho halogenation of N-aryl amides and ureas via oxidative halodeboronation: harnessing boron reactivity for efficient C–halogen bond installation

Published:2023 Issue:46 Volume:14 Page:13429-13436
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shinde Ganesh H.¹^ORCID,Ghotekar Ganesh S.¹^ORCID,Amombo Noa Francoise M.²,Öhrström Lars²^ORCID,Norrby Per-Ola³^ORCID,Sundén Henrik¹²^ORCID

Affiliation:

1. Department of Chemistry and Molecular Biology, University of Gothenburg, SE-41296 Gothenburg, Sweden

2. Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden

3. Data Science and Modelling, Pharmaceutical Sciences, R&D, AstraZeneca Gothenburg, Pepparedsleden 1, Mölndal SE-43183, Sweden

Abstract

We report the discovery of an ortho regioselective oxidative halodeboronation of N-aryl amides and ureas with wide-ranging applications in pharmaceuticals, materials science, and synthetic organic chemistry.

Funder

Adlerbertska Research Foundation

Olle Engkvists Stiftelse

Carl Tryggers Stiftelse för Vetenskaplig Forskning

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC04628A

Reference61 articles.

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