Orosomucoid binding induced amplification of inherent chirality of the immunosuppressant drug sirolimus
Author:
Affiliation:
1. Research Group of Chemical Biology
2. Institute of Organic Chemistry
3. Research Centre for Natural Sciences
4. Hungarian Academy of Sciences
5. Budapest
Abstract
Orosomucoid binding provoked helical distortion of the triene moiety of sirolimus results in a new, intense CD band.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA14546E
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2. HUMAN ALPHA-1-GLYCOPROTEIN AND ITS INTERACTIONS WITH DRUGS†,‡
3. The Orosomucoid 1 protein is involved in the vitamin D – mediated macrophage de-activation process
4. α1-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties
5. The 1.8-Å Crystal Structure of α1-Acid Glycoprotein (Orosomucoid) Solved by UV RIP Reveals the Broad Drug-Binding Activity of This Human Plasma Lipocalin
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